Introduction Lung cancer is the second most prevalent cancer and the leading cause of cancer mortality worldwide, with an estimated 2.2 million new cases and 1.8 million new deaths in 2020 (Sung et al, 2021). Despite the emergence of novel targeted therapy …
Introduction The innate immune system plays a fundamental role in recognising and responding to invading pathogens and damage signals. One important component of this response is the inflammasome, a multiprotein complex that upon activation and assembly …
Introduction Inflammasomes play a central role in orchestrating innate and adaptive immune responses. Assembly of these intracellular multi-protein complexes results in recruitment and activation of caspase-1. This protease is a prototypic and …
CXCR4 is expressed on all B-cell subsets during B-cell development from HSCs to antibody-secreting cells. However, the level of the expression of the receptor varies over time, allowing B-lineage cells to progress in their development and maturation (Aiuti …
Introduction Leptospirosis is a zoonotic bacterial infectious disease that affects both humans and commercially relevant animals. The disease is widely distributed geographically and transmitted through direct or indirect exposure to the urine of infected …
Introduction The elongation phase of RNA polymerase II (RNAPII) transcription is associated with a highly conserved, stereotypical pattern of histone post-translational modifications. Its key features include monoubiquitylation of histone H2B (throughout …
Human papillomavirus (HPV) infections account for several human cancers. There is an urgent need to develop therapeutic vaccines for targeting preexisting high-risk HPV (such as HPV 16 and 18) infections and lesions, which are insensitive to preventative …
Introduction The mucin MUC1 is a transmembrane glycoprotein expressed by epithelial cells at different mucosal surfaces including the breast tissue, airways, and gastrointestinal tract. The full-length MUC1 protein extends 200–500 nm from the apical …
Introduction The maintenance of exact membrane lipid composition is important for providing a distinct identity to cellular organelles and thus for supporting normal cellular physiology (Harayama & Riezman, 2018). Various lipid species reach their …
Results Identification of a selective SIRT4-C-RAF interaction among SIRT and RAF protein family members In a previous study, we employed mass spectrometry and proteomic analysis to identify novel SIRT4-interacting proteins (Bergmann et al, 2020). …
Marmoset fibroblast reprogramming into cjiPSCs To further establish the marmoset monkey as a model for studying germ cell development in vitro, we first generated a panel of cjiPSC lines. We followed our previously described approach to derive iPSCs from …
Introduction Central nervous system (CNS) tumors can arise at any age and have the highest cancer-associated mortality rate in pediatric patients (Ostrom et al, 2019). Atypical teratoid/rhabdoid tumors (AT/RTs), medulloblastomas (MBs), and choroid plexus …
Introduction Centriole biogenesis has to be tightly controlled to prevent aberrant centrosome number, which can lead to chromosome missegregation and aneuploidy and has been associated with cancer (Nigg & Holland, 2018). Centriole duplication is …
Correction: Corrigendum Panagiota Kolitsida, Vladimir Nolic, Jianwen Zhou, Michael Stumpe, Natalie M Niemi, Jörn Dengjel, Hagai Abeliovich Life Science Alliance Mar 2024, 7 (6) e202402684; DOI: 10.26508/lsa.202402684
Introduction The G2/M transition is a critical preparatory step for the equal separation of genetic material between the daughter cells, which is crucial for cell physiology. The mitosis onset is under the surveillance of checkpoints, which are signaling …
Abstract The mitochondrial contact site and cristae organizing system (MICOS) is important for crista junction formation and for maintaining inner mitochondrial membrane architecture. A key component of the MICOS complex is MIC60, which has been well …
Introduction Dysregulation of the blood–brain barrier is associated with the pathogenesis of a variety of diseases, including infectious causes such as cerebral malaria and noninfectious causes such as multifactorial neurodegenerative diseases (Miller et …
Introduction Starvation is a severe form of malnutrition that occurs when an individual’s intake of food is inadequate to meet their body’s energy requirements. Prolonged starvation can cause permanent organ damage, stunted growth in children, and …
Introduction The tumor microenvironment is a key promoter of tumorigenesis (Hannahan & Weinberg, 2011). Peripheral nerve tumors caused by loss of the NF1 tumor suppressor provide a unique system in which to study the roles of the tumor microenvironment …
Results HAPSTR1 is not a cofactor for canonical HUWE1-mediated ubiquitination The remarkably similar phenotypes of HAPSTR1 and HUWE1 loss at the level of cellular fitness and transcriptome-wide signaling (Amici et al, 2022), as well as their epistatic …
