Introduction With the current advances in DNA sequence technology, in the past two decades, there was a rapid acceleration in the genomic resources of food crops and in the development of tools and technologies that use this vast amount of genomic sequence …
Introduction Interstitial fluid is collected by blind-ended initial lymphatic vessels and transported further to precollecting and collecting lymphatic vessels back to the blood circulation (Alitalo, 2011). The uptake of fluid by initial lymphatic vessels …
Introduction Eukaryotic mRNA translation is a highly regulated multistep process that regulates protein synthesis under normal and stress conditions. mRNA translation is largely divided into three steps: initiation, elongation, and termination (1). In …
Introduction Inflammation is the body’s evolutionarily selected immune response to infection or tissue damage. It not only results in the activation and consumption of immune cells but is also accompanied by significant alterations in the function and …
Introduction Animal development is shaped by the activity of several highly conserved signalling pathways (Ingham & McMahon, 2001; Wiese et al, 2018; Herrera & Bach, 2019). One such pathway is the Notch signalling pathway which, through the core …
Introduction In eukaryotic cells, posttranslational protein modification by ubiquitin regulates nearly every cellular pathway, including the defense against bacteria and other intracellular pathogens. Several Gram-negative bacterial species are taken up by …
Introduction The number of neurons generated in the brain neocortex is determined by the proliferative capacity of a relatively small number of neural progenitor cells (NPCs) (Noctor et al, 2004; Gotz & Huttner, 2005). The proliferative capacity of …
Introduction Thyroid cancer (TC) is the most prevalent endocrine cancer, and its incidence rate has been rapidly increasing during the past few decades (Chen et al, 2023). Papillary thyroid cancer (PTC) comprises 80% of all malignant thyroid tumors, …
Introduction Homologous recombination (HR) is an evolutionarily conserved process that plays a pivotal role in genome stability, diversity, and plasticity. HR is indeed a key repair pathway able to faithfully repair DNA damages including double-strand …
High-throughput omics technologies have generated a wealth of large protein, gene, and transcript datasets that have exacerbated the need for new methods to analyse and compare big datasets. Rank–rank hypergeometric overlap is an important threshold-free …
Introduction T cells have a key role in immune-mediated host protection from cancer, infection, and autoimmune diseases. Activation of T cells requires ligand binding by cell surface receptors, which initiate downstream signal transduction cascades (Smith- …
Article: Cutano V, Ferreira Mendes JM, Escudeiro-Lopes S, Machado S, Vinaixa Forner J, Gonzales-Morena JM, Prevorovsky M, Zemlianski V, Feng Y, Kralova Viziova P, Hartmanova A, Malcekova B, Jakoube P, Iyer S, Keckesova Z (2022 Nov 14) LACTB exerts tumor …
Introduction Bipolar affective disorder (BPAD) is a human psychiatric illness characterized by disruptive mood swings; the defining characteristics being the alteration between mania and depression associated with an elevated rate of suicide among patients …
Introduction Mitochondria attached to lipid droplets (LDs), or peridroplet mitochondria (PDM), were shown to expand lipid droplets in brown adipose tissue (BAT) (Benador et al, 2018). Mechanistically, BAT PDM are specialized to oxidize pyruvate and provide …
Chromosome (SMC) proteins are a large family of ATPases that play important roles in the organization and dynamics of chromatin. They are central regulators of chromosome dynamics and the core component of condensin. DNA elimination during zygotic somatic …
Introduction Prostate cancer (PCa) is the third most common cancer among men by incidence (14.1%) and the fifth in terms of cancer-related mortality worldwide (among men, 7%) (1). In Australia, Western Europe, and North America, PCa is the most commonly …
Correction: Pantethine boosts anti-sarcoma immunity Richard Miallot, Virginie Millet, Anais Roger, Romain Fenouil, Catherine Tardivel, Jean-Charles Martin, Fabrice Tranchida, Laetitia Shintu, Paul Berchard, Juliane Sousa Lanza, Bernard Malissen, Sandrine …
Introduction Oxford Nanopore Technologies (ONT) direct RNA sequencing (Fig 1A) enables detection of RNA modifications. A modified base produces an altered electrical current and/or dwell time relative to a canonical base that can be detected with …
Introduction Mutations in the BRCA2 gene are associated with a high risk of developing breast, ovarian, and other types of cancers (Wooster et al, 1995; Ozçelik et al, 1997; Breast Cancer Linkage Consortium, 1999; Antoniou et al, 2003; Edwards et al, 2003; …
Introduction Heart disease, the leading cause of mortality in the world, results from irreversible cardiomyocyte loss after tissue damage such as ischemic injury (Roth et al, 2020; Virani et al, 2021). Extensive basic, translational, and clinical research …
