Life Science Alliance - New York Press Releases

• Published on April 5, 2023 - 15:30 GMT

  

  Retinitis pigmentosa-associated mutations in mouse Prpf8 cause misexpression of circRNAs and degeneration of cerebellar granule ...

  Introduction The PRPF8 protein is the central scaffolding component of the spliceosome, which organizes its catalytic RNA core and directly regulates the activity of the key spliceosomal RNA helicase SNRNP200 (also known as Brr2) to control correct timing …

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• Published on April 5, 2023 - 14:30 GMT

  

  Multidimensional conservation analysis decodes the expression of conserved long noncoding RNAs

  Introduction The transcriptional landscape is far more complex than initially thought, as most of the genomic sequence is pervasively transcribed into a wide variety of RNAs (Berretta & Morillon, 2009; Djebali et al, 2012). A substantial portion of RNA …

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• Published on April 5, 2023 - 14:30 GMT

  

  Validating organoid-derived human intestinal monolayers for personalized therapy in cystic fibrosis

  Introduction Cystic fibrosis (CF) is caused by variants in the CFTR gene resulting in impaired anion transport across epithelial barriers and consequently to multi-organ disease including the lungs, liver, and gastrointestinal tract (O’Sullivan & …

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• Published on April 5, 2023 - 14:30 GMT

  

  An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity

  Introduction Mitochondria operate as major hubs regulating cell life and death. By providing energy through the electron transport chain (ETC), they also generate reactive oxygen species (ROS) that may be detrimental to tumor survival. Functional and/or …

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• Published on April 3, 2023 - 15:59 GMT

  

  arfA antisense RNA regulates MscL excretory activity

  Introduction Bacteria are subject to numerous and occasionally drastic intracellular challenges and extracellular perturbations to which they respond by triggering their defence mechanisms through the expression of stress-responsive genes (1, 2). These …

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• Published on April 3, 2023 - 15:59 GMT

  

  The ubiquitin-like modifier FAT10 is degraded by the 20S proteasome in vitro but not in cellulo

  Results FAT10 is degraded by the 20S proteasome in vitro Several in vitro studies showed that the 20S proteasome actively recognizes and degrades oxidized proteins and proteins with inherent structural disorders. Degradation by the 20S proteasome does not …

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• Published on April 3, 2023 - 15:59 GMT

  

  Dynamic changes of enhancer and super enhancer landscape in degenerated nucleus pulposus cells

  Introduction Low back pain (LBP) is a common disease, the economic loss and social burden caused by LBP in people aged 25–74 ranked fourth (Vlaeyen et al, 2018), of which 40% were related to intervertebral disc degeneration (IDD) (Zehra et al, 2022). The …

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• Published on March 31, 2023 - 13:20 GMT

  RopB represses the transcription of speB in the absence of SIP in group A Streptococcus

  RopB is a quorum-sensing regulator that binds to the SpeB-inducing peptide (SIP) under acidic conditions. SIP is known to be degraded by the endopeptidase PepO, whose transcription is repressed by the CovR/CovS two-component regulatory system. Both SIP- …

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• Published on March 30, 2023 - 16:30 GMT

  UPF3A is dispensable for nonsense-mediated mRNA decay in mouse pluripotent and somatic cells

  Nonsense-mediated mRNA decay (NMD) is a highly conserved regulatory mechanism of post-transcriptional gene expression in eukaryotic cells. NMD plays essential roles in mRNA quality and quantity control and thus safeguards multiple biological processes …

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• Published on March 30, 2023 - 13:09 GMT

  

  Bats experience age-related hearing loss (presbycusis)

  Introduction Population aging in humans is an international concern (Sanderson & Scherbov, 2010). Aging is the driving factor of various disorders such as neurodegenerative and cardiovascular diseases, cancer, and metabolic diseases (Booth & Brunet …

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• Published on March 28, 2023 - 18:08 GMT

  

  The association of lipid transfer protein VPS13A with endosomes is mediated by sorting nexin SNX5

  Introduction Cellular homeostasis requires the correct traffic of lipids from their main source of synthesis, the endoplasmic reticulum, to their final destination in the membrane of the different organelles. In recent years, the importance of lipid …

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• Published on March 28, 2023 - 18:08 GMT

  FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins

  Staphylococcus aureus causes severe infections such as pneumonia and sepsis depending on the pore-forming toxin Panton–Valentine leukocidin (PVL). PVL kills and induces inflammation in macrophages and other myeloid cells by interacting with the human cell …

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• Published on March 28, 2023 - 18:08 GMT

  

  The role of Limch1 alternative splicing in skeletal muscle function

  Introduction Postnatal skeletal muscle development is a period of dynamic change as the tissue undergoes extensive remodeling to meet new functional demands. A significant aspect of this process is the regulated alternative splicing of hundreds of genes, …

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• Published on March 28, 2023 - 18:08 GMT

  Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1

  The IFN system constitutes a powerful antiviral defense machinery. Consequently, effective IFN responses protect against severe COVID-19 and exogenous IFNs inhibit SARS-CoV-2 in vitro. However, emerging SARS-CoV-2 variants of concern (VOCs) may have …

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• Published on March 27, 2023 - 16:50 GMT

  

  Crystal structures of dimeric and heptameric mtHsp60 reveal the mechanism of chaperonin inactivation

  Introduction Heat shock protein 60 (Hsp60), also known as chaperonin, is a widely conserved gene found in all living kingdoms (Zeilstra-Ryalls et al, 1991; Gupta, 1995; Bukau & Horwich, 1998; Zhao & Liu, 2017). Chaperonins play a crucial role in …

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• Published on March 24, 2023 - 16:22 GMT

  

  Interaction hub critical for telomerase recruitment and primer-template handling for catalysis

  Introduction Telomeres are nucleoprotein complexes that protect the ends of linear eukaryotic chromosomes from genome instability. Telomeric DNA is bound to the six-protein shelterin complex that protects these ends from being misrecognized as DNA damage …

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• Published on March 23, 2023 - 18:02 GMT

  

  Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii

  Introduction Ubiquitination is a highly conserved post-translational modification found across archaea, bacteria, and eukaryotes and plays important roles in nearly every cellular process. Protein modification with ubiquitin takes on a multitude of …

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• Published on March 21, 2023 - 15:37 GMT

  

  Cell death and barrier disruption by clinically used iodine concentrations

  Abstract Povidone-iodine (PVP-I) inactivates a broad range of pathogens. Despite its widespread use over decades, the safety of PVP-I remains controversial. Its extended use in the current SARS-CoV-2 virus pandemic urges the need to clarify safety features …

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• Published on March 20, 2023 - 17:55 GMT

  

  Structure-based design and characterization of Parkin-activating mutations

  Introduction Mutations in the PRKN (Kitada et al, 1998) and PINK1 (Valente et al, 2004) genes account for most of the recessive early-onset Parkinson’s disease (PD) cases (Martin et al, 2011). The PRKN gene encodes Parkin, an E3 ubiquitin (Ub) ligase that …

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• Published on March 20, 2023 - 16:39 GMT

  MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimers disease

  Extracellular circulating microRNAs (miRNAs) have been discussed as potential biomarkers for Alzheimer’s disease (AD) diagnosis. As the retina is a part of the CNS, we hypothesize that miRNAs expression levels in the brain, particularly neocortex– …

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