Broad Institute of MIT and Harvard Press Releases

• Published on October 11, 2023 - 15:00 GMT

  

  A research team searches for every gene that helps tumors evade immunotherapy

  As Manguso was wrapping up his PhD work in 2017, he, Haining (now at Arsenal Biosciences), and Kathleen Yates, an immunologist in Haining’s lab with a track record of executing large, complex projects, began to think big about the approach they were taking …

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• Published on August 31, 2023 - 15:00 GMT

  

  Evolved prime editors are smaller and more efficient for therapeutic applications

  Prime editing technologies allow scientists to precisely edit the genome in a variety of ways and could one day be used to treat genetic diseases. Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory …

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• Published on August 14, 2023 - 15:00 GMT

  

  Three studies highlight how proteins are altered in multiple cancer types

  Over the past two decades, scientists have shed light on the genetic mutations that drive cancer. More recently, they are focusing on proteins to understand the biological events in cancer cells that lead to disease. In three new studies, researchers …

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• Published on July 19, 2023 - 18:00 GMT

  

  Researchers reprogram gene therapy viral vectors to bind specific protein targets

  In 2019, Deverman’s group identified the protein that serves as a receptor for AAV-PHP.B, a capsid that is efficiently transported across the blood-brain barrier. That made them wonder whether they could develop a screening approach that would find more …

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• Published on June 28, 2023 - 14:42 GMT

  

  How chromosome imbalances can drive cancer

  The vast majority of cancer cells have too few or too many copies of some chromosomes, a state known as aneuploidy. But for decades, researchers have debated whether aneuploidy promotes the growth of cancers, or is simply a side effect of cancer cells’ …

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• Published on April 20, 2023 - 15:05 GMT

  

  Scientists use genetics to dig into a tumor’s past

  For patients with some types of cancer, diagnosis can happen at an advanced stage. While a tumor grows unnoticed, it accumulates hundreds to thousands of mutations, making it difficult for scientists studying late-stage cancers to figure out which ones …

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• Published on April 18, 2023 - 14:51 GMT

  

  Lung cancer’s molecular features shed light on immunotherapy response

  One of the newest types of cancer drugs, immunotherapies called immune checkpoint inhibitors, has transformed the treatment of lung cancer over the last decade — dramatically improving the survival of some patients with the most common form of this disease …

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• Published on March 30, 2023 - 18:00 GMT

  

  Base editing treats spinal muscular atrophy in mice

  Researchers have used a gene-editing technique called base editing to restore motor function to near-normal levels in a mouse model of spinal muscular atrophy (SMA) — a disease that leads to paralysis and, in its most severe form, death before the age of …

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• Published on March 29, 2023 - 15:00 GMT

  

  Bacterial injection system delivers proteins in mice and human cells

  Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have harnessed a natural bacterial system to develop a new protein delivery approach that works in human cells and animals. The technology, described …

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• Published on February 22, 2023 - 22:00 GMT

  

  Several pre-existing RSV lineages powered the 2022 surge

  Late last year, thousands of children across the United States were hospitalized with respiratory syncytial virus (RSV), but unlike previous RSV surges, this one affected a larger number of people and a broader range of age groups, including older children …

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• Published on October 31, 2022 - 16:53 GMT

  

  First large genetic study of bipolar disorder in Asian populations launches

  Nearly 60 percent of the world’s population resides in Asian countries, but only 10 percent of participants of genetic studies are of Asian descent. And that disparity is even greater in studies of psychiatric conditions, where participants are almost all …

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• Published on April 6, 2022 - 15:00 GMT

  

  Two large studies reveal genes and genome regions that influence schizophrenia risk

  In a landmark genetic study of more than 121,000 people, an international consortium called SCHEMA, led by researchers at the Broad Institute of MIT and Harvard, has identified extremely rare protein-disrupting mutations in 10 genes that strongly increase …

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• Published on March 18, 2019 - 04:05 GMT

  

  Sumaiya Iqbal is using computer science to bridge genetics and therapeutics

  When a 15-year-old Sumaiya Iqbal was asked about her career aspirations in a televised profile series about the most promising young students in Bangladesh, she confidently responded that she wanted to become “a scientist.” At the time, she was thinking of …

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• Published on March 15, 2019 - 17:21 GMT

  

  Research Roundup: March 15, 2019

  Welcome to the March 15, 2019 installment of Research Roundup, a recurring snapshot of recent studies published by scientists at the Broad Institute and their collaborators. A data flood from young bloods For a systems biology look at how the human body …

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• Published on March 8, 2019 - 16:48 GMT

  

  Research Roundup: March 8, 2019

  Welcome to the March 8, 2019 installment of Research Roundup, a recurring snapshot of recent studies published by scientists at the Broad Institute and their collaborators. Exhausted, but still effective It’s unclear how anti-PD1 “checkpoint-blockade” …

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