Broad Institute of MIT and Harvard Press Releases - EIN Presswire

Published on March 25, 2025 - 14:44 GMT

An effort based at Broad is fostering dialogue between autism researchers, advocates, and families

In recent years, public discussions about autism, autism research, and individuals with autism have revealed a wide range of views, at times becoming contentious. Autism researchers at the Broad Institute of MIT and Harvard noticed that the discourse …

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Published on March 12, 2025 - 17:08 GMT

New technology puts a spatial lens on CRISPR screening

Recently, scientists have been able to explore gene circuitry in individual cells using methods that suppress particular genes and measure the impact on the expression of other genes. These methods, however, fail to capture spatial information such as the …

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Published on March 11, 2025 - 21:11 GMT

Count Me In launches new patient-partnered research project for translocation renal cell carcinoma

Count Me In, a patient-partnered research initiative led by the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute, is launching a new project focused on translocation renal cell carcinoma (tRCC), a rare and aggressive form of kidney …

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Published on March 6, 2025 - 15:55 GMT

Studies reveal new genetic roots of atrial fibrillation

Two studies led by researchers at the Broad Institute of MIT and Harvard and Mass General Brigham have greatly expanded the number of known genetic variants that boost the risk for atrial fibrillation (AF), a common heart condition marked by irregular …

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Published on February 28, 2025 - 03:23 GMT

An ancient RNA-guided system could simplify delivery of gene editing therapies

A vast search of natural diversity has led scientists at MIT’s McGovern Institute and the Broad Institute of MIT and Harvard to uncover ancient systems with the potential to expand the genome editing toolbox. These systems, which the researchers call TIGR …

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Published on February 27, 2025 - 04:14 GMT

Why brain cancer is often resistant to immunotherapy

Immunotherapy has revolutionized the treatment of many cancers, but brain tumors such as gliomas remain particularly difficult to treat, in part because they potently suppress immune responses. New findings from researchers at the Broad Institute of MIT …

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Published on February 19, 2025 - 01:56 GMT

Alex Rives joins faculty of Broad Institute and MIT

Broad Institute of MIT and Harvard has appointed Alex Rives, a leading computer scientist and pioneering artificial intelligence researcher, as a core institute member. Rives will also serve as an assistant professor in the Department of Electrical …

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Published on February 11, 2025 - 15:56 GMT

Mapping mRNA through its life cycle within a cell

When Xiao Wang applied to faculty jobs, many of the institutions where she interviewed thought her research proposal — to study the life cycle of RNA in cells and how it influences normal development and disease — was too broad. However, that was not the …

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Published on February 6, 2025 - 00:25 GMT

Mutations in two gene pairs point to a promising drug target in 5 percent of adult cancers

Scientists from the Cancer Dependency Map (DepMap) at the Broad Institute of MIT and Harvard and Columbia University have discovered that about 5 percent of adult cancers rely heavily on a gene called PELO to survive and that disabling the gene kills those …

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Published on January 27, 2025 - 17:08 GMT

A genome-wide atlas of cell morphology reveals gene functions

Visualizing cells after editing specific genes can help scientists learn new details about the function of those genes. But using microscopy to do this at scale can be challenging, particularly when studying thousands of genes at a time. Now, researchers …

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Published on January 16, 2025 - 17:07 GMT

Study finds surprising way that genetic mutation causes Huntington’s disease, transforming understanding of the disorder

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington’s disease leads to the death of brain cells. The …

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Published on January 14, 2025 - 16:58 GMT

Gene editing extends lifespan in mouse model of prion disease

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition. The treatment, which uses base editing to …

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Published on January 13, 2025 - 18:39 GMT

Broad Institute and Manifold collaborate to build AI-enabled life sciences research platform to accelerate global discoveries

The Broad Institute of MIT and Harvard today announced a strategic collaboration with Manifold, a leader in research infrastructure for biomedical science, to develop a cutting-edge research platform. This initiative expands on Broad’s vision for …

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Published on January 9, 2025 - 21:12 GMT

Scientists engineer CRISPR enzymes that evade the immune system

The core components of CRISPR-based genome-editing therapies are bacterial proteins called nucleases that can stimulate unwanted immune responses in people, increasing the chances of side effects and making these therapies potentially less effective. …

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Published on January 7, 2025 - 22:00 GMT

A clinical genomicist harnesses team-based science to help rare-disease patients

And though there is still a long way to go — about half of rare disease patients remain undiagnosed — Rehm’s fingerprints can be found on many of the standards and tools that have allowed clinical geneticists to increase their diagnostic success rate over …

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Published on January 7, 2025 - 01:36 GMT

Feng Zhang awarded the National Medal of Technology and Innovation

In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks. We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap). Broad …

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Published on January 6, 2025 - 18:48 GMT

Researchers devise new way to target and correct disease-related proteins

Over the past two decades, large genetic studies have linked tens of thousands of DNA variants to thousands of human traits and diseases. Yet, correcting the effects of those variants to treat disease has been hampered in part by the lack of precise …

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Published on December 11, 2024 - 16:09 GMT

#WhyIScience Q&A: A computational biologist’s world travels have shaped her approach to research

During her highly unusual college experience traveling the world, Wolu Chukwu saw the power of communities. She attended Minerva University, a San Francisco-based college that rotates its students to a different country each semester while they take online …

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Published on December 10, 2024 - 00:48 GMT

Q&A: How a Broad team uses cutting-edge spatial technologies to enable new science

As a young researcher-in-training at Harvard, chemical biologist Sami Farhi helped develop an innovative technology that can visualize the electrical activity of brain cells. Near the end of his graduate studies in 2018, he lamented the fact that …

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Published on November 21, 2024 - 22:11 GMT

Researchers identify source of a brain cancer’s deadly transformation

Gliomas are the most common brain tumors, and many start off growing slowly as “low-grade” tumors before inevitably becoming aggressive, lethal, and “high grade.” New research offers an explanation for this deadly transformation. In a study published in …

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