Broad Institute of MIT and Harvard Press Releases - EIN Presswire

Published on December 11, 2024 - 16:09 GMT

#WhyIScience Q&A: A computational biologist’s world travels have shaped her approach to research

During her highly unusual college experience traveling the world, Wolu Chukwu saw the power of communities. She attended Minerva University, a San Francisco-based college that rotates its students to a different country each semester while they take online …

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Published on December 10, 2024 - 00:48 GMT

Q&A: How a Broad team uses cutting-edge spatial technologies to enable new science

As a young researcher-in-training at Harvard, chemical biologist Sami Farhi helped develop an innovative technology that can visualize the electrical activity of brain cells. Near the end of his graduate studies in 2018, he lamented the fact that …

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Published on November 21, 2024 - 23:50 GMT

Researchers identify source of a brain cancer’s deadly transformation

Gliomas are the most common brain tumors, and many start off growing slowly as “low-grade” tumors before inevitably becoming aggressive, lethal, and “high grade.” New research offers an explanation for this deadly transformation. In a study published in …

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Published on November 21, 2024 - 23:37 GMT

Scientists find a region of the mouse gut tightly regulated by the immune system

The intestine maintains a delicate balance in the body, absorbing nutrients and water while maintaining a healthy relationship with the gut microbiome, but this equilibrium is disrupted in parts of the intestine in conditions such as celiac disease, …

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Published on November 7, 2024 - 01:18 GMT

Study reveals how cancer immunotherapy may cause heart inflammation in some patients

Some patients being treated with immune checkpoint inhibitors, a type of cancer immunotherapy, develop a dangerous form of heart inflammation called myocarditis. Researchers led by physicians and scientists at the Broad Institute of MIT and Harvard and …

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Published on November 7, 2024 - 01:18 GMT

Q&A: How a partnership between physicians and researchers aims to make cancer drugs safer

In the mid-2010s, oncologist Kerry Reynolds and colleagues at Mass General Hospital noticed an alarming pattern: more and more patients undergoing cancer treatment were coming to the hospital gravely ill, not from the cancer but from the medicine itself. …

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Published on November 5, 2024 - 02:54 GMT

A transatlantic collaboration is uncovering the role of key genetic variants in common diseases like type 2 diabetes and obesity

Like many research endeavors, the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease at the Broad Institute of MIT and Harvard (NNFC) grew out of a conversation between scientists. Kasper Lage, a Danish-born researcher at Broad, and Niels- …

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Published on October 31, 2024 - 01:15 GMT

Researchers map communities of single cells in metastatic breast cancers

A single biopsy from a metastatic breast cancer tumor contains hundreds of thousands of cells – some cancerous and others part of the complex web of immune cells, blood vessels, and supportive tissue that surround a tumor. Researchers have typically …

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Published on October 29, 2024 - 23:27 GMT

New drug triggers rapid cell death in cancer models

A team of researchers at Broad Institute of MIT and Harvard, in a long-term project that has included industry collaborators at Bayer and Trueline Therapeutics, has developed a compound called BRD-810 that holds promise as a therapeutic candidate for …

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Published on October 28, 2024 - 18:41 GMT

New machine learning-based single-cell search engine makes cell annotation faster, more efficient

One of the first steps for researchers in studying and analyzing single cells is to determine the cells’ identity: what type and subtype of cells are these, and how similar or different are they to previously analyzed cells? Scientists then annotate the …

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Published on October 24, 2024 - 06:26 GMT

Machine learning guides researchers to new synthetic genetic switches

Researchers at The Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types. …

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Published on October 24, 2024 - 06:26 GMT

To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives

The research team found that Emma and the two other children from unrelated families each lack a chunk of DNA in one copy of a gene called CHASERR. This gene is unlike a traditional gene, which encodes RNA that translates into a protein capable of …

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Published on October 22, 2024 - 00:18 GMT

New diagnostic approach for bacterial infections shows promise in the clinic

For patients with bacterial infections, the sooner they are treated with the appropriate antibiotics, the better they will fare. Current methods for determining which drugs might work for each patient rely on growing bacteria from the patient in the lab …

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Published on October 17, 2024 - 20:50 GMT

New diagnostic approach for bacterial infections shows promise in the clinic

For patients with bacterial infections, the sooner they are treated with the appropriate antibiotics, the better they will fare. Current methods for determining which drugs might work for each patient rely on growing bacteria from the patient in the lab …

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Published on October 16, 2024 - 18:07 GMT

F. William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce ...

The 2024 Richard N. Merkin Prize in Biomedical Technology was awarded to F. William Studier of Brookhaven National Laboratory in a ceremony and symposium at the Broad Institute on September 17, 2024. The prize, created by the Merkin Family Foundation and …

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Published on October 15, 2024 - 23:46 GMT

#WhyIScience Q&A: A microbiologist and immunologist finds links between our own microbes and disease mechanisms

Though his focus shifted over time, being a scientist was always the plan for Eric Brown since kindergarten. “First it was dinosaurs and whales, and then it turned into birds, and then it turned into microbes,” he said. Years later, Brown began studying …

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Published on October 3, 2024 - 22:12 GMT

Largest-ever genetic study of epilepsy finds possible therapeutic targets

The largest and most diverse study to date of epilepsy’s genetic factors has revealed new potential targets for treatment, both shared by and unique to different subtypes of epilepsy. The findings point to factors involved in how neurons communicate and …

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Published on September 30, 2024 - 21:53 GMT

Q&A: How Terra became a backbone of public health pathogen surveillance

DP: Before Terra, only a handful of state public health labs were analyzing their own genomic data. Most didn't really have a way to do large-scale genomic analysis well. Many relied on the CDC, a neighboring state lab, or an academic partner to assist …

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Published on September 23, 2024 - 17:23 GMT

New approach may yield modified messenger RNAs for treating a wide range of conditions

The life-saving use of messenger RNA (mRNA) in COVID-19 vaccines was a public example of the potential of mRNA-based therapies, which hold great promise for a wide range of treatment applications from cancer immunotherapy to gene editing. Working toward a …

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Published on September 18, 2024 - 17:06 GMT

Scientists identify a unique combination of bacterial strains that could treat antibiotic-resistant gut infections

Antibiotic-resistant bacterial infections often occur in patients with chronic inflammatory intestinal conditions, such as inflammatory bowel disease, and in patients who have taken antibiotics for a long time. Gram-negative bacteria such as …

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