Spatial transcriptomics technologies opened the door for new kinds of biological measurements, allowing scientists to generate detailed maps of where genes are expressed in tissue. But most methods rely on expensive and time-intensive imaging that requires …
When Maddie Murphy, a computational associate at the Broad Institute of MIT and Harvard, first learned she’d have the opportunity to pursue her research in Copenhagen, she envisioned a two- or three-week visit. Then her supervisor, Ray Jones, told her she …
When Maddie Murphy, a computational associate at the Broad Institute of MIT and Harvard, first learned she’d have the opportunity to pursue her research in Copenhagen, she envisioned a two- or three-week visit. Then her supervisor, Ray Jones, told her she …
In recent years, public discussions about autism, autism research, and individuals with autism have revealed a wide range of views, at times becoming contentious. Autism researchers at the Broad Institute of MIT and Harvard noticed that the discourse …
Recently, scientists have been able to explore gene circuitry in individual cells using methods that suppress particular genes and measure the impact on the expression of other genes. These methods, however, fail to capture spatial information such as the …
Count Me In, a patient-partnered research initiative led by the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute, is launching a new project focused on translocation renal cell carcinoma (tRCC), a rare and aggressive form of kidney …
Two studies led by researchers at the Broad Institute of MIT and Harvard and Mass General Brigham have greatly expanded the number of known genetic variants that boost the risk for atrial fibrillation (AF), a common heart condition marked by irregular …
A vast search of natural diversity has led scientists at MIT’s McGovern Institute and the Broad Institute of MIT and Harvard to uncover ancient systems with the potential to expand the genome editing toolbox. These systems, which the researchers call TIGR …
Immunotherapy has revolutionized the treatment of many cancers, but brain tumors such as gliomas remain particularly difficult to treat, in part because they potently suppress immune responses. New findings from researchers at the Broad Institute of MIT …
Broad Institute of MIT and Harvard has appointed Alex Rives, a leading computer scientist and pioneering artificial intelligence researcher, as a core institute member. Rives will also serve as an assistant professor in the Department of Electrical …
When Xiao Wang applied to faculty jobs, many of the institutions where she interviewed thought her research proposal — to study the life cycle of RNA in cells and how it influences normal development and disease — was too broad. However, that was not the …
Scientists from the Cancer Dependency Map (DepMap) at the Broad Institute of MIT and Harvard and Columbia University have discovered that about 5 percent of adult cancers rely heavily on a gene called PELO to survive and that disabling the gene kills those …
Visualizing cells after editing specific genes can help scientists learn new details about the function of those genes. But using microscopy to do this at scale can be challenging, particularly when studying thousands of genes at a time. Now, researchers …
Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington’s disease leads to the death of brain cells. The …
Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition. The treatment, which uses base editing to …
The Broad Institute of MIT and Harvard today announced a strategic collaboration with Manifold, a leader in research infrastructure for biomedical science, to develop a cutting-edge research platform. This initiative expands on Broad’s vision for …
The core components of CRISPR-based genome-editing therapies are bacterial proteins called nucleases that can stimulate unwanted immune responses in people, increasing the chances of side effects and making these therapies potentially less effective. …
And though there is still a long way to go — about half of rare disease patients remain undiagnosed — Rehm’s fingerprints can be found on many of the standards and tools that have allowed clinical geneticists to increase their diagnostic success rate over …
In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks. We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap). Broad …
Over the past two decades, large genetic studies have linked tens of thousands of DNA variants to thousands of human traits and diseases. Yet, correcting the effects of those variants to treat disease has been hampered in part by the lack of precise …
