Broad Institute of MIT and Harvard Press Releases - EIN Presswire

Published on May 8, 2025 - 01:41 GMT

How the Novo Nordisk Foundation Center at Broad is using scalable technologies and AI to find the root cause of diabetes

Since the earliest days of her scientific career, Melina Claussnitzer, a metabolic disease researcher at the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease (NNFC) at the Broad Institute, has been thinking about how to accelerate the …

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Published on May 1, 2025 - 03:37 GMT

Sentinel program among finalists for the $100 Million 100&Change competition

The MacArthur Foundation and its nonprofit affiliate, Lever for Change, have announced the Sentinel program as one of five finalists in the 100&Change competition. 100&Change is a global competition awarding a single $100 million grant to help …

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Published on April 16, 2025 - 16:22 GMT

WhyIScience Q&A: How a chemist moved to the business side of science

Diane Diehl excelled in math and science as a student, but in high school, she also got a taste for business. During summers, she worked at her father’s small engineering firm in Wheeling, Illinois, managing the office, handling payroll, and making sure …

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Published on April 10, 2025 - 21:38 GMT

Potential Alzheimer’s disease therapeutic target identified in brain immune cells

Since the 1990s, researchers have found several immune system molecules that act like “brakes” on immune responses, leading to a new class of cancer drugs. One of these “immune checkpoint” molecules, called Tim-3 has recently been linked to late-onset …

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Published on April 6, 2025 - 10:42 GMT

David Liu receives Breakthrough Prize in Life Sciences

Gene editing pioneer David Liu, a core member at the Broad Institute where he is the Richard Merkin Professor and director of the Merkin Institute for Transformative Technologies in Healthcare, has been named a laureate of the 2025 Breakthrough Prize in …

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Published on April 4, 2025 - 03:38 GMT

Scientists have developed a way to scale up spatial genomics and lower costs

Spatial transcriptomics technologies opened the door for new kinds of biological measurements, allowing scientists to generate detailed maps of where genes are expressed in tissue. But most methods rely on expensive and time-intensive imaging that requires …

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Published on March 28, 2025 - 02:17 GMT

A Novo Nordisk - Broad collaboration is connecting Denmark-based and Broad researchers

When Maddie Murphy, a computational associate at the Broad Institute of MIT and Harvard, first learned she’d have the opportunity to pursue her research in Copenhagen, she envisioned a two- or three-week visit. Then her supervisor, Ray Jones, told her she …

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Published on March 27, 2025 - 17:19 GMT

Building bridges between Denmark-based and Broad researchers

When Maddie Murphy, a computational associate at the Broad Institute of MIT and Harvard, first learned she’d have the opportunity to pursue her research in Copenhagen, she envisioned a two- or three-week visit. Then her supervisor, Ray Jones, told her she …

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Published on March 25, 2025 - 14:44 GMT

An effort based at Broad is fostering dialogue between autism researchers, advocates, and families

In recent years, public discussions about autism, autism research, and individuals with autism have revealed a wide range of views, at times becoming contentious. Autism researchers at the Broad Institute of MIT and Harvard noticed that the discourse …

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Published on March 13, 2025 - 03:11 GMT

New technology puts a spatial lens on CRISPR screening

Recently, scientists have been able to explore gene circuitry in individual cells using methods that suppress particular genes and measure the impact on the expression of other genes. These methods, however, fail to capture spatial information such as the …

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Published on March 11, 2025 - 21:17 GMT

Count Me In launches new patient-partnered research project for translocation renal cell carcinoma

Count Me In, a patient-partnered research initiative led by the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute, is launching a new project focused on translocation renal cell carcinoma (tRCC), a rare and aggressive form of kidney …

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Published on March 7, 2025 - 02:21 GMT

Studies reveal new genetic roots of atrial fibrillation

Two studies led by researchers at the Broad Institute of MIT and Harvard and Mass General Brigham have greatly expanded the number of known genetic variants that boost the risk for atrial fibrillation (AF), a common heart condition marked by irregular …

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Published on February 28, 2025 - 03:34 GMT

An ancient RNA-guided system could simplify delivery of gene editing therapies

A vast search of natural diversity has led scientists at MIT’s McGovern Institute and the Broad Institute of MIT and Harvard to uncover ancient systems with the potential to expand the genome editing toolbox. These systems, which the researchers call TIGR …

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Published on February 27, 2025 - 04:31 GMT

Why brain cancer is often resistant to immunotherapy

Immunotherapy has revolutionized the treatment of many cancers, but brain tumors such as gliomas remain particularly difficult to treat, in part because they potently suppress immune responses. New findings from researchers at the Broad Institute of MIT …

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Published on February 19, 2025 - 02:11 GMT

Alex Rives joins faculty of Broad Institute and MIT

Broad Institute of MIT and Harvard has appointed Alex Rives, a leading computer scientist and pioneering artificial intelligence researcher, as a core institute member. Rives will also serve as an assistant professor in the Department of Electrical …

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Published on February 11, 2025 - 15:56 GMT

Mapping mRNA through its life cycle within a cell

When Xiao Wang applied to faculty jobs, many of the institutions where she interviewed thought her research proposal — to study the life cycle of RNA in cells and how it influences normal development and disease — was too broad. However, that was not the …

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Published on February 6, 2025 - 00:42 GMT

Mutations in two gene pairs point to a promising drug target in 5 percent of adult cancers

Scientists from the Cancer Dependency Map (DepMap) at the Broad Institute of MIT and Harvard and Columbia University have discovered that about 5 percent of adult cancers rely heavily on a gene called PELO to survive and that disabling the gene kills those …

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Published on January 27, 2025 - 17:13 GMT

A genome-wide atlas of cell morphology reveals gene functions

Visualizing cells after editing specific genes can help scientists learn new details about the function of those genes. But using microscopy to do this at scale can be challenging, particularly when studying thousands of genes at a time. Now, researchers …

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Published on January 17, 2025 - 01:11 GMT

Study finds surprising way that genetic mutation causes Huntington’s disease, transforming understanding of the disorder

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington’s disease leads to the death of brain cells. The …

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Published on January 15, 2025 - 02:11 GMT

Gene editing extends lifespan in mouse model of prion disease

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition. The treatment, which uses base editing to …

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