Broad Institute of MIT and Harvard Press Releases - EIN Presswire

Published on October 17, 2025 - 08:26 GMT

Broad-Bayer collaboration leads to drug candidate for a hard-to-treat type of lung cancer

An alliance of scientists at the Broad Institute and Bayer Pharmaceuticals have developed a drug candidate, sevabertinib, that could be a new treatment for a group of lung cancer patients who have few options today. In a new study published in Cancer …

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Published on October 16, 2025 - 08:10 GMT

Broad Clinical Labs sets new GUINNESS WORLD RECORDS™ title for fastest DNA sequencing technique

Broad Clinical Labs, in collaboration with Roche Sequencing Solutions and Boston Children’s Hospital, today announced official recognition by Guinness World Records for achieving the fastest DNA sequencing technique to date. Leveraging Roche’s new SBX …

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Published on October 9, 2025 - 05:07 GMT

A pioneering effort in patient-partnered cancer research enters a new phase

In 2015, an innovative research initiative called Count Me In launched to give every patient with cancer, no matter where they lived, a way to contribute directly to research and help accelerate advances that could one day lead to new treatments. Since …

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Published on October 1, 2025 - 01:57 GMT

Jason Buenrostro named core institute member at Broad

Broad Institute has appointed Jason Buenrostro as a core institute member. Buenrostro, a leading epigenomics researcher and technology developer, will also join the leadership team of the Epigenomics Program at Broad. Buenrostro is a professor in the …

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Published on September 25, 2025 - 23:07 GMT

Study identifies genetic targets that could improve CAR-T therapies

Researchers from Mass General Brigham and the Broad Institute of MIT and Harvard have identified genetic modifications that can improve the efficacy of chimeric antigen receptor (CAR)-T cell treatment — an immunotherapy that uses modified patient T cells …

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Published on September 23, 2025 - 01:55 GMT

New AI-based diagnostic tool uses epigenomics to accelerate acute leukemia diagnosis

Researchers at Dana-Farber Cancer Institute and the Broad Institute have developed an artificial intelligence-based diagnostic tool that could transform the way acute leukemia is identified and treated. The tool, called MARLIN (Methylation- and AI-guided …

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Published on September 11, 2025 - 00:45 GMT

#WhyIScience Q&A: A structural biologist adopts a new role catalyzing collaborations

Although Gail Guo’s parents had no formal scientific training, she fondly recalls their curiosity and frequent chats about research discoveries during her childhood in China. They also told Gail about her aunt who’d studied chemistry and moved to the US to …

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Published on September 9, 2025 - 03:42 GMT

Remembering David Baltimore

Many of you will have heard by now the sad news that David Baltimore passed away on Saturday morning. The New York Times obituary describes David’s roles as one of the greatest scientists and scientific leaders of his generation. His legendary …

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Published on September 4, 2025 - 00:58 GMT

How massive datasets generated at Broad are powering the latest AI models in biology

In June, Google DeepMind took the wraps off AlphaGenome, its latest machine learning model for biological discovery. While DeepMind's Nobel Prize-winning AlphaFold model focuses on proteins and how they fold, AlphaGenome predicts how genetic variants …

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Published on September 4, 2025 - 00:58 GMT

Mass General Brigham launches genetic test to predict risk across eight cardiovascular conditions

In a step forward for genomic-driven preventive medicine, Mass General Brigham Personalized Medicine and the Massachusetts General Hospital’s Cardiovascular Disease Prevention Center and Center for Genomic Medicine today announced the launch of an …

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Published on August 23, 2025 - 05:10 GMT

Breast cancer therapy can raise uterine cancer risk through a unique mechanism

Studies show that people receiving tamoxifen, a highly effective and commonly used therapy to treat breast cancer, face a 2- to 7-fold increased risk of developing uterine cancer within 2-5 years of tamoxifen treatment compared to the general population. …

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Published on August 15, 2025 - 13:02 GMT

Using artificial intelligence, researchers design new compounds that kill antibiotic-resistant bacteria

With help from artificial intelligence, researchers from MIT, the Whitehead Institute for Biomedical Research, the Wyss Institute for Biologically Inspired Engineering, and the Broad Institute of MIT and Harvard have designed novel antibiotics that can …

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Published on August 9, 2025 - 04:02 GMT

Blood-based test provides new diagnostic approach for multiple myeloma

Researchers at Dana-Farber Cancer Institute, Massachusetts General Hospital (MGH), and the Broad Institute have developed a blood test that could transform the diagnosis and monitoring of multiple myeloma (MM) and its precursor conditions. The new method, …

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Published on August 7, 2025 - 15:19 GMT

Boston Children’s Hospital, Dana-Farber Cancer Institute, and Broad Clinical Labs launch precision genomics initiative for ...

In a pioneering collaboration aimed at transforming pediatric cancer diagnostics and research, Boston Children’s Hospital (BCH), Dana-Farber Cancer Institute (DFCI), and Broad Clinical Labs have announced the formation of BrightSeq (Boston Research in …

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Published on August 7, 2025 - 06:08 GMT

Scientists develop technology that brings new precision to genome editing

The FDA’s recent approval of the first CRISPR-Cas9–based gene therapy marked a major milestone in biomedicine, validating genome editing as a promising treatment strategy for disorders like sickle cell disease, muscular dystrophy, and certain cancers. …

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Published on August 6, 2025 - 23:43 GMT

Breathing low-oxygen air slows Parkinson’s progression in mice

Researchers from the Broad Institute and Mass General Brigham have shown that a low-oxygen environment — similar to the thin air found at Mount Everest base camp — can protect the brain and restore movement in mice with Parkinson’s-like disease. The new …

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Published on August 2, 2025 - 03:16 GMT

Genomics points to potential targeted treatment options for pediatric gliomas

A collaborative study between Dana-Farber Cancer Institute and the Broad Institute found that 8.9 percent of children with glioma, the most common form of pediatric brain tumor, have alterations in the fibroblast growth factor receptor (FGFR) family of …

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Published on August 1, 2025 - 04:39 GMT

Study finds biomarkers, drug targets, risk factors for most common form of lung cancer

By analyzing tens of thousands of genes, proteins, and protein modifications in hundreds of lung tumors, an international research team has uncovered new factors linked to poor outcomes in lung adenocarcinoma in both smokers and people who have never …

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Published on July 30, 2025 - 05:30 GMT

Collaboration aims to reduce animal use in drug safety testing

Roughly a third of drug candidates fail in the first phase of clinical trials, often due to unanticipated toxic effects that weren’t apparent in animal tests. A consortium co-led by Broad Institute scientists is building tools and datasets to reduce the …

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Published on July 25, 2025 - 08:02 GMT

Scientists apply optical pooled CRISPR screening to identify potential new Ebola drug targets

Although outbreaks of Ebola virus are rare, the disease is severe and often fatal, with few treatment options. Rather than targeting the virus itself, one promising therapeutic approach would be to interrupt proteins in the human host cell that the virus …

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