Broad Institute of MIT and Harvard Press Releases - EIN Presswire

Published on April 14, 2026 - 19:20 GMT

Cancer Dependency Map Consortium launches Phase 3 to accelerate next-generation therapeutics

The Broad Institute’s Cancer Dependency Map Consortium (DMC) is an academic-industry collaboration that has transformed the study of cancer by developing one of the most comprehensive inventories of tumor vulnerabilities. Launched in late 2018, the DMC is …

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Published on April 14, 2026 - 13:00 GMT

Base editing repairs mutation and liver function in mouse model of Zellweger spectrum disorder

The authors tested two different base editors in mice — one called ABE8e and a modified version called ABE8e-V106W — and found that both efficiently corrected the PEX1 mutation, but ABE8e-V106W was significantly better tolerated in the animals and made …

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Published on April 11, 2026 - 03:40 GMT

Leukemia cells use a sugar-coated protein to hide from the immune system

Leukemia is adept at dodging the immune system, making it resistant to many of the newest generation of cancer immunotherapies. Now, researchers have identified a key part of the cancer’s disguise: a protein called CD43 on the surface of leukemia cells …

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Published on March 31, 2026 - 15:19 GMT

Scalable cell imaging method could help make drug safety testing faster, cheaper

Many drug candidates fail in early-stage clinical trials because of toxic effects in humans that weren’t seen in animal tests. Testing these chemicals in human cells in the lab could help detect these adverse effects sooner and at lower cost, while …

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Published on March 26, 2026 - 18:46 GMT

Malaria-transmitting mosquitoes in South America are evolving to evade insecticides

Anopheles darlingi mosquitoes — a major vector of malaria in South America—are evolving in response to insecticides, which may make them harder to kill and malaria more difficult to control, according to a new study led by Harvard T.H. Chan School of …

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Published on March 25, 2026 - 16:01 GMT

A new view into viruses in the body

Some viruses make us sick and are cleared within days by the immune system, but other viruses lurk in our bodies for a lifetime and can re-emerge later to cause new problems. How and why viral levels change in the body over time — and the health impacts of …

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Published on March 25, 2026 - 16:00 GMT

How inflammation may prime the gut for cancer

Chronic inflammation can raise a person’s risk of cancer, and a new study reveals key details about how that might happen in the gut and points to better ways to identify and reduce risk. Scientists at the Broad Institute and Harvard University have …

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Published on March 19, 2026 - 14:32 GMT

Mutation reveals connection between schizophrenia and brain circuit needed to incorporate new information

One of the symptoms of schizophrenia is difficulty incorporating new information about the world. This can lead people with schizophrenia to struggle with making decisions and, eventually, to lose touch with reality. Neuroscientists from the Broad …

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Published on March 12, 2026 - 15:36 GMT

Stanley Family Foundation renews commitment to accelerate psychiatric research at Broad Institute

The Stanley Family Foundation has renewed its commitment to psychiatric research at the Broad Institute, bringing its total investment to more than $1 billion. This funding, including their newest commitment of $280 million to the Stanley Center for …

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Published on March 4, 2026 - 16:37 GMT

Gut bacteria rewire fat tissue to burn more energy

Most adult body fat consists of white fat cells that store excess calories, but babies are born with stores of brown and beige fat that burn energy to generate heat. Brown fat levels decrease with age, but scientists have long sought to change that, …

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Published on February 27, 2026 - 00:20 GMT

Study reveals genetic balancing act between autoimmunity and cancer risk

An autoimmune disorder that affects the thyroid gland, called autoimmune hypothyroidism (AIHT), is the most common autoimmune disease, yet it remains largely understudied. New research from scientists at Broad Institute, University of Helsinki, and other …

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Published on February 26, 2026 - 00:55 GMT

Free genetic testing program aims to improve medical care across Alabama

An initiative aimed at improving medical care and addressing chronic disease is now underway in Alabama. Catalyst, a precision medicine program led by the Alabama nonprofit Southern Research in collaboration with Broad Clinical Labs at the Broad Institute …

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Published on February 25, 2026 - 21:28 GMT

Scientists sharpen genetic maps to help pinpoint DNA changes that influence human health traits and disease risk

Scientists have identified how specific genetic changes function in cells to influence disease risk and other human health traits. By probing regions of DNA previously linked to disease, the work has created high resolution maps of DNA variant activity, …

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Published on February 22, 2026 - 22:52 GMT

Broad's campus will be open Monday for essential onsite activities only

Broad Institute's gene-editing technologies—CRISPR-Cas9, base editing, and prime editing—are being tested in more than 25 clinical trials to treat or cure leukemias, rare genetic diseases, high cholesterol, and other conditions. NIH-funded discoveries …

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Published on February 10, 2026 - 02:34 GMT

Clinical trial explores whether a genetic test can improve early detection of prostate cancer

A genetic test developed by researchers at Broad Clinical Labs and the U.S. Department of Veterans Affairs (VA) is now enabling a large, nationwide clinical trial aimed at improving health care for men at increased risk of developing prostate cancer, the …

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Published on February 2, 2026 - 22:53 GMT

Feng Zhang inducted into National Inventors Hall of Fame

Broad Institute core member Feng Zhang, along with 15 other innovators, will be inducted into the National Inventors Hall of Fame. In partnership with the United States Patent and Trademark Office, the Hall of Fame will honor the latest class of inductees …

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Published on January 28, 2026 - 20:37 GMT

How genes influence the microbes in our mouths

No matter how much they brush their teeth, some people still get more cavities than others, in part because of differences in genetics and the make-up of the microbes in their mouths. A new study has found human genetic factors that influence the oral …

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Published on January 24, 2026 - 04:04 GMT

AI generates short DNA sequences that show promise for gene therapies

Scientists at the Broad Institute and Mass General Brigham have built a generative AI model that creates short DNA segments that can control gene activity in specific cells. These sequences, called cis-regulatory elements (CREs), make up a large part of …

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Published on January 17, 2026 - 09:14 GMT

Scientists develop molecules that may treat Crohn’s disease

An estimated 3 million Americans have an inflammatory bowel disease (IBD) such as Crohn’s disease or ulcerative colitis. But a lucky few individuals are far less likely to develop IBD because they have a rare variant of a gene called CARD9. This protective …

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Published on January 7, 2026 - 20:55 GMT

Researchers uncover molecular roots of fibrosis or tissue scarring in inflammatory bowel disease

When inflammation in the body goes unchecked, it can cause fibrosis, or tissue scarring that may lead to organ dysfunction or even failure. This can happen in conditions such as inflammatory bowel diseases (ulcerative colitis and Crohn’s disease), chronic …

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