Broad Institute of MIT and Harvard Press Releases - EIN Presswire

Published on June 11, 2024 - 19:30 GMT

#WhyIScience Q&A: A biochemist uses mass spectrometry to find proteins involved in cancer

When Moe Haines first moved from Beirut, Lebanon to the United States for college, his goal was to earn a degree in pharmacy. Haines was the first person in his family to pursue science, and most people he knew with similar interests had chosen a career in …

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Published on June 10, 2024 - 17:17 GMT

Improved prime editing system makes gene-sized edits in human cells at therapeutic levels

Scientists at the Broad Institute of MIT and Harvard have improved a gene-editing technology that is now capable of inserting or substituting entire genes in the genome in human cells efficiently enough to be potentially useful for therapeutic applications …

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Published on May 16, 2024 - 18:00 GMT

New gene delivery vehicle shows promise for human brain gene therapy

In an important step toward more effective gene therapies for brain diseases, researchers from the Broad Institute of MIT and Harvard have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver …

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Published on May 14, 2024 - 12:45 GMT

Merkin Prize in Biomedical Technology awarded to F. William Studier for development of widely used protein- and RNA-production ...

“The T7 system has been influential in biomedicine and has had important clinical implications for many years, but Bill Studier’s contribution to the field has really not been as celebrated as it ought to be,” said Harold Varmus, chair of the Merkin Prize …

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Published on May 9, 2024 - 12:30 GMT

Calico and Broad Institute extend collaboration, adding focus on age-related neurodegeneration

In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks. We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap). Broad …

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Published on May 2, 2024 - 14:00 GMT

#WhyIScience Q&A: How a computational biologist balances work with life as an elite rower

Tell us a bit about your research. Why are you studying autopsy samples from cancer patients? Cancers can develop many paths to drug resistance and it’s important to understand how every cell in a cancer develops resistance. If you have a primary tumor …

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Published on May 1, 2024 - 20:02 GMT

Scientists work out the effects of exercise at the cellular level

The health benefits of exercise are well known but new research shows that the body’s response to exercise is more complex and far-reaching than previously thought. In a study on rats, a team of scientists from across the United States has found that …

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Published on April 25, 2024 - 15:16 GMT

A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic

“Pardis and Christian have created an environment where we can collaborate closely with our colleagues in West Africa, which gives us a deep understanding of what the current system looks like and where tools can fill in the gaps,” said Colby Wilkason, …

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Published on April 18, 2024 - 13:56 GMT

Scientists uncover 95 regions of the genome linked to PTSD

In posttraumatic stress disorder (PTSD), intrusive thoughts, changes in mood, and other symptoms after exposure to trauma can greatly impact a person’s quality of life. About 6 percent of people who experience trauma develop the disorder, but scientists …

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Published on April 2, 2024 - 15:00 GMT

Scientists link certain gut bacteria to lower heart disease risk

Changes in the gut microbiome have been implicated in a range of diseases including type 2 diabetes, obesity, and inflammatory bowel disease. Now, a team of researchers at the Broad Institute of MIT and Harvard along with Massachusetts General Hospital has …

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Published on March 26, 2024 - 18:56 GMT

Ancient DNA reveals possible origin of a racial/ethnic disparity in a childhood cancer

People who identify as Hispanic/Latino have the highest risk of a blood cancer called acute lymphoblastic leukemia (ALL) compared to other populations in the US, with 40 percent more Hispanic/Latino children being diagnosed than non-Hispanic white children …

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Published on March 25, 2024 - 17:32 GMT

#WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers

After watching the Jane Goodall news segment, how did you make your way to pursuing higher education? In my high school biology class, we watched a video of a cell dividing and I remember thinking, “How is that possible? How does that happen?” It was just …

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Published on March 22, 2024 - 10:11 GMT

Messenger RNAs with multiple “tails” could lead to more effective therapeutics

Messenger RNA (mRNA) made its big leap into the public limelight during the pandemic, thanks to its cornerstone role in several COVID-19 vaccines. But mRNAs, which are genetic sequences that instruct the body to produce proteins, are also being developed …

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Published on March 20, 2024 - 18:14 GMT

Spatial study of lung cancer reveals immune markers of response to immunotherapy

Most patients with cancer who are treated with immunotherapies called PD-1 inhibitors don’t respond to the treatments and many researchers have been trying to figure out why by studying immune cells in human tumors. Scientists at the Broad Institute of MIT …

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Published on March 19, 2024 - 15:00 GMT

Researchers roll out a more accurate way to estimate genetic risks of disease

A new scoring approach featured in Cell Genomics and developed by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital (MGH) uses a comprehensive approach to generate more accurate and informative PRSs. Aptly named …

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Published on March 14, 2024 - 19:29 GMT

Scientists generate new targeted protein degradation system that tunes a cell’s own proteins

Researchers studying the role of proteins in health and disease use experimental tools that inactivate proteins, destroy them, or prevent them from being made in cells. In one approach, they mark targeted proteins with “destroy me” tags that work with …

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Published on March 8, 2024 - 15:02 GMT

Study reveals genetic clusters that may explain differences in type 2 diabetes risk

The development and progression of type 2 diabetes are affected by numerous biological processes, such as the body’s response to insulin, the health of insulin-producing pancreatic beta cells, and the functioning of metabolic pathways. In a recent study …

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Published on March 8, 2024 - 15:00 GMT

A close research partnership with African scientists helps solve the mystery of malaria-like illnesses

Why did you and your colleagues in Senegal decide to do this study? Siddle: This project was somewhat born out of a sense that there was relatively limited diagnostic testing available. Senegalese clinicians told us that lack of diagnostics was a source …

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Published on March 6, 2024 - 16:00 GMT

Schizophrenia and aging may share a common biological basis

Researchers from the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have uncovered a strikingly similar suite of changes in gene activity in brain tissue from people with …

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Published on January 30, 2024 - 10:00 GMT

Battling antibiotic resistance in the lab and the clinic

After his infectious disease training at MGH and Brigham and Women’s Hospital (BWH), Bhattacharyya served as chief resident at MGH and began considering his future as a physician-scientist. He saw how genomic technology had progressed during the seven …

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