In posttraumatic stress disorder (PTSD), intrusive thoughts, changes in mood, and other symptoms after exposure to trauma can greatly impact a person’s quality of life. About 6 percent of people who experience trauma develop the disorder, but scientists …
Changes in the gut microbiome have been implicated in a range of diseases including type 2 diabetes, obesity, and inflammatory bowel disease. Now, a team of researchers at the Broad Institute of MIT and Harvard along with Massachusetts General Hospital has …
People who identify as Hispanic/Latino have the highest risk of a blood cancer called acute lymphoblastic leukemia (ALL) compared to other populations in the US, with 40 percent more Hispanic/Latino children being diagnosed than non-Hispanic white children …
After watching the Jane Goodall news segment, how did you make your way to pursuing higher education? In my high school biology class, we watched a video of a cell dividing and I remember thinking, “How is that possible? How does that happen?” It was just …
Messenger RNA (mRNA) made its big leap into the public limelight during the pandemic, thanks to its cornerstone role in several COVID-19 vaccines. But mRNAs, which are genetic sequences that instruct the body to produce proteins, are also being developed …
Most patients with cancer who are treated with immunotherapies called PD-1 inhibitors don’t respond to the treatments and many researchers have been trying to figure out why by studying immune cells in human tumors. Scientists at the Broad Institute of MIT …
A new scoring approach featured in Cell Genomics and developed by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital (MGH) uses a comprehensive approach to generate more accurate and informative PRSs. Aptly named …
Researchers studying the role of proteins in health and disease use experimental tools that inactivate proteins, destroy them, or prevent them from being made in cells. In one approach, they mark targeted proteins with “destroy me” tags that work with …
The development and progression of type 2 diabetes are affected by numerous biological processes, such as the body’s response to insulin, the health of insulin-producing pancreatic beta cells, and the functioning of metabolic pathways. In a recent study …
Why did you and your colleagues in Senegal decide to do this study? Siddle: This project was somewhat born out of a sense that there was relatively limited diagnostic testing available. Senegalese clinicians told us that lack of diagnostics was a source …
Researchers from the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have uncovered a strikingly similar suite of changes in gene activity in brain tissue from people with …
After his infectious disease training at MGH and Brigham and Women’s Hospital (BWH), Bhattacharyya served as chief resident at MGH and began considering his future as a physician-scientist. He saw how genomic technology had progressed during the seven …
Tumors depend heavily on certain genetic changes to thrive, and researchers have discovered many such “genetic dependencies” as targets for potential new cancer drugs. At the Broad Institute of MIT and Harvard and elsewhere, researchers are also learning …
In the early 1900s, a cook named Mary Mallon, better known as “Typhoid Mary”, spread Salmonella Typhi, the causative agent of typhoid fever, to dozens of her patrons even though she showed no symptoms. Many people today harbor pathogenic Salmonella …
Scientists have developed two agents, made of therapeutic nanoparticles and antibodies, that could be given to patients shortly before a blood draw to allow physicians to better detect tumor DNA in blood using a technology called liquid biopsy. Liquid …
Prime editing, a versatile form of gene editing that can correct most known disease-causing genetic mutations, now has a new vehicle to deliver its machinery into cells in living animals. A team of researchers at the Broad Institute of MIT and Harvard has …
Psychiatric and neurological disorders are widespread, yet the pace of drug development for these conditions lags far behind that of heart disease, cancer, and other conditions. Brain disorders are difficult to study and many drug candidates have failed in …
As Manguso was wrapping up his PhD work in 2017, he, Haining (now at Arsenal Biosciences), and Kathleen Yates, an immunologist in Haining’s lab with a track record of executing large, complex projects, began to think big about the approach they were taking …
Manguso and Kathleen Yates at the Broad co-direct TIDE, which uses CRISPR screens and other tools in animals to systematically uncover genes such as PTPN2 that cancers use to evade immunotherapy. Hakimeh Ebrahimi-Nik, a senior research scientist in TIDE, …
Prime editing technologies allow scientists to precisely edit the genome in a variety of ways and could one day be used to treat genetic diseases. Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory …
