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Published on April 2, 2025 - 12:10 GMT

YTHDF1 Identified As a Potential Therapeutic Target for Autoimmune Hepatitis

New Study Underscores The Pivotal Role Of YTHDF1 In Immune-Mediated Hepatitis CHINA, April 2, 2025 /⁨EINPresswire.com⁩/ -- Autoimmune hepatitis (AIH) is a severe autoimmune disease characterized by immune-mediated hepatocyte destruction, leading to …

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Published on March 28, 2025 - 12:24 GMT

Sexual Dimorphism in Cystinuria- The Mitochondria Link

Unravelling the role of mitochondrial Slc3a1 in regulating mitochondrial functions and sexual dimorphism in cystinuria CHINA, March 28, 2025 /⁨EINPresswire.com⁩/ -- Cystinuria is the most common inheritable cause of kidney stone disease, characterized by …

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Published on March 28, 2025 - 12:00 GMT

Comprehensive Genomic and Epigenomic Characterization of Iridocorneal Endothelial Syndrome

New Study Unravels The Underlying Mechanisms Of ICE Syndrome CHINA, March 28, 2025 /⁨EINPresswire.com⁩/ -- Iridocorneal endothelial (ICE) syndrome is a rare, irreversibly blinding ocular disorder with an unknown etiology. Lack of targeted effective drugs, …

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Published on March 28, 2025 - 11:48 GMT

Inhibiting Sphingosine-1-Phosphate Receptor 3 (S1PR3) Mitigates Pulmonary Fibrosis

S1pr3 knockdown ameliorates bleomycin-induced pulmonary fibrosis by reducing macrophage M2 polarization CHINA, March 28, 2025 /⁨EINPresswire.com⁩/ -- Pulmonary fibrosis (PF) involves the excessive accumulation of extracellular matrix, resulting in the …

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Published on March 28, 2025 - 11:48 GMT

High-Mobility Group Nucleosomal-Binding Domain 2: A Prognostic Indicator and A New Therapeutic Target for Gliomas

New Study Unveils Novel Direction For The Treatment Of Glioblastoma Multiforme CHINA, March 28, 2025 /⁨EINPresswire.com⁩/ -- Glioblastoma multiforme (GBM), commonly referred to as glioblastoma, is a malignant intracranial tumor derived from glial cells, …

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Published on March 18, 2025 - 08:15 GMT

Isoleucyl-tRNA Synthetase 2 (IARS2) Promotes Pancreatic Ductal Adenocarcinoma (PDAC)

IARS2 facilitates PDAC proliferation and metastasis by stabilizing β-catenin and activating the WNT/β-catenin pathway. CHINA, March 18, 2025 /⁨EINPresswire.com⁩/ -- Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related …

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Published on March 18, 2025 - 07:51 GMT

Immune Subtyping and NK Cell Targeting: Optimizing Immune Checkpoint Inhibitor Therapy in Hepatocellular Carcinoma

- New Study Unveils Novel Classification Approach for Predicting ICI Response in HCC Patients CHINA, March 18, 2025 /⁨EINPresswire.com⁩/ -- Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, accounts for about 75–85% of all …

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Published on March 17, 2025 - 11:21 GMT

Transcriptional Landscape of PDAC Shows Distinct Cell Populations

Single-cell RNA sequencing (scRNA-seq) on a PDAC cohort identified distinct cell populations associated with tumor initiation and progression CHINA, March 17, 2025 /⁨EINPresswire.com⁩/ -- Pancreatic cancer is one of the leading causes of cancer-related …

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Published on March 17, 2025 - 11:08 GMT

SPP1+ Macrophages Identified as Key Drivers and Therapeutic Targets In Colorectal Cancer Progression

New Study Unveils Critical Role of SPP1+ Macrophages in Colorectal Cancer Progression and Treatment CHINA, March 17, 2025 /⁨EINPresswire.com⁩/ -- Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related …

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Published on March 13, 2025 - 13:03 GMT

IL2RG Gene Therapy for X-SCID

Pre-clinical validation of SIN-EFS-IL2RG.co vector-based gene therapy for X-SCID CHINA, March 13, 2025 /⁨EINPresswire.com⁩/ -- X-linked severe combined immunodeficiency disease (X-SCID) is a rare genetic disorder characterized by profound defects in T- …

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Published on March 13, 2025 - 12:38 GMT

Innovative Study Highlights BMP9 and SHH as Key Drivers of Bone Repair

New Research Highlights Synergistic Role of BMP9 and Shh in Bone Regeneration CHINA, March 13, 2025 /⁨EINPresswire.com⁩/ -- Bone morphogenetic proteins (BMPs) directly affect the osteogenic differentiation of stem cells and are integral to bone tissue …

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Published on March 11, 2025 - 06:20 GMT

Delineating the Mechanisms Mediating Piezo-1- Induced Liver Regeneration

Theoretical basis for mechanical stimulation-mediated chemical signals-induced liver regeneration CHINA, March 11, 2025 /⁨EINPresswire.com⁩/ -- Liver regeneration (LR) is a complex biological process involving the proliferation of parenchymal (hepatocytes …

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Published on March 11, 2025 - 06:01 GMT

AI-Driven Advancements in Neuroblastoma Diagnosis and Bone/Bone Marrow Metastasis Prediction

Groundbreaking Study Unveils Key Mechanisms in Neuroblastoma Bone and Bone Marrow Metastasis CHINA, March 11, 2025 /⁨EINPresswire.com⁩/ -- Neuroblastoma (NB), the most prevalent extracranial solid tumor among children, is characterized by a high rate of …

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Published on March 10, 2025 - 20:34 GMT

New Insights into tRNA-Derived Small RNAs Offer Hope for Digestive Tract Disease Diagnosis and Treatment

SHANNON, CLARE, IRELAND, March 10, 2025 /⁨EINPresswire.com⁩/ -- This new article published in Genes & Diseases highlights the critical role of tRNA-derived small RNAs (tsRNAs) in digestive tract diseases, positioning these molecules as potential …

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Published on March 10, 2025 - 20:31 GMT

New Avenues for Treating Metabolic Dysfunction-Associated Fatty Liver Disease

SHANNON, CLARE, IRELAND, March 10, 2025 /⁨EINPresswire.com⁩/ -- Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a growing global health concern, affecting millions worldwide. This complex liver disorder ranges from simple steatosis …

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Published on March 10, 2025 - 20:28 GMT

ELF4: A Key Transcription Factor Shaping Immunity and Cancer Progression

SHANNON, CLARE, IRELAND, March 10, 2025 /⁨EINPresswire.com⁩/ -- ELF4, a transcription factor belonging to the ETS family, has emerged as a pivotal regulator in cell differentiation, immune system function, and cancer progression. This newly published …

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Published on March 10, 2025 - 20:26 GMT

The Role of lncRNAs in Kidney Disease: A Breakthrough in Biomarker Discovery and Therapeutic Approaches

SHANNON, CLARE, IRELAND, March 10, 2025 /⁨EINPresswire.com⁩/ -- A new review published in Genes & Diseases on long non-coding RNAs (lncRNAs) highlights their critical role in the development, diagnosis, and potential treatment of acute kidney injury ( …

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Published on March 10, 2025 - 20:23 GMT

New Avenues in Breast Cancer Treatment: The Role of Ubiquitin-Specific Proteases in Programmed Cell Death

SHANNON, CLARE, IRELAND, March 10, 2025 /⁨EINPresswire.com⁩/ -- This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among …

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Published on March 10, 2025 - 20:19 GMT

Traditional Chinese Medicine Unlocks New Potential in Treating Diseases Through Ferroptosis Regulation

SHANNON, CLARE, IRELAND, March 10, 2025 /⁨EINPresswire.com⁩/ -- Innovative insights into the role of ferroptosis, a unique form of programmed cell death, are reshaping the landscape of disease treatment. This growing field highlights how Traditional …

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Published on March 10, 2025 - 20:15 GMT

Unveiling the Role of Tumor-Infiltrating Immune Cells in Endometrial Carcinoma

SHANNON, CLARE, IRELAND, March 10, 2025 /⁨EINPresswire.com⁩/ -- A new review article published in Genes & Diseases sheds light on the complex molecular mechanisms through which tumor-infiltrating immune cells regulate endometrial carcinoma (EC). As one …

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