Up to half of patients with Crohn’s disease, an inflammatory bowel disease, develop a complication called fibrosis, where the gut becomes scarred and obstructed, causing pain and bloating. Currently, the only treatment option for these gut “strictures” is …
In May 2025, researchers announced that K.J. Muldoon, a baby boy born without the ability to process dietary protein properly, had become the first person to be treated with a customized gene editing therapy. Based on a technology developed by Broad …
At first, Giulia Monti thought she’d work in another neuroscience lab as a postdoctoral researcher. She had spent the last four years earning her PhD at Aarhus University in Denmark, studying proteins called cargo receptors in Alzheimer’s disease. But then …
The Broad Institute and Bayer have extended their cardiovascular research collaboration of 10 years by an additional five years, further advancing their work in human genomics research in cardiovascular diseases. First launched in 2015 and renewed in 2020, …
Broad Institute researchers have developed a technology that provides new insight into how disruptions in the nucleus of the cell can impact health and disease. The approach, called expansion in situ genome sequencing, allows scientists to sequence DNA and …
Researchers have created a pipeline for discovering unique combinations of molecules that increase the effectiveness of antibiotics against drug-resistant bacteria. The team, led by scientists at the Broad Institute and the Tufts University School of …
Broad Institute researchers have developed a way to edit the genetic sequences at the root of Huntington’s disease and Friedreich’s ataxia. The conditions are two of more than 40 severe neurological disorders caused by three-letter stretches of DNA that …
Researchers from around 29 universities and institutions across North America have teamed up to create a large, versatile, and effective arsenal of new biological tools that will play a critical role in the battle against brain disease. The tools are known …
A new risk assessment score developed by researchers at Dana-Farber Cancer Institute, the Broad Institute of MIT and Harvard, and Massachusetts General Hospital reveals how multiple myeloma, a form of blood cancer, begins and progresses from precancerous …
Four biomedical innovators — Carl June, Bruce Levine, Isabelle Rivière, and Michel Sadelain — have been jointly awarded the 2025 Richard N. Merkin Prize in Biomedical Technology for developing chimeric antigen receptor (CAR) T-cell therapy, a …
Cancers of the biliary tract system affect the network of ducts that connect the liver, gallbladder, and small intestine, and are aggressive, killing 9 out of 10 patients within just a few years of diagnosis. New research from the Broad Institute and …
A new direct-to-participant effort now underway is giving people the opportunity to participate in the largest and most diverse genetic study of anorexia nervosa and other eating disorders to date. Researchers at the Broad Institute Ben Neale and Mark Daly …
A protein located in the wrong part of a cell can contribute to several diseases, such as Alzheimer’s, cystic fibrosis, and cancer. But there are about 70,000 different proteins and protein variants in a single human cell, and since scientists can …
Researchers from the Broad Institute and Columbia University have developed a way to insert entire healthy genes into human cells efficiently enough for potential therapeutic applications. It lays a foundation for gene-editing therapies for patients with …
Scientists at the McGovern Institute and the Broad Institute of MIT and Harvard have reengineered a compact RNA-guided enzyme they found in bacteria into an efficient, programmable editor of human DNA. The engineered protein, called NovaIscB, can be …
A new AI model developed by researchers at the Eric and Wendy Schmidt Center at the Broad Institute and ETH Zurich’s Department of Health Science and Technology can identify genes that have been altered, such as ones that might be causing a disease, in a …
Growing up in the Sichuan province in China, Bo Xia was curious about the nature he saw around him: the creeks that ran through his hometown and its many animals and insects. In school, he loved imagining how molecules made up materials and whole organisms …
Since the earliest days of her scientific career, Melina Claussnitzer, a metabolic disease researcher at the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease (NNFC) at the Broad Institute, has been thinking about how to accelerate the …
The MacArthur Foundation and its nonprofit affiliate, Lever for Change, have announced the Sentinel program as one of five finalists in the 100&Change competition. 100&Change is a global competition awarding a single $100 million grant to help …
Diane Diehl excelled in math and science as a student, but in high school, she also got a taste for business. During summers, she worked at her father’s small engineering firm in Wheeling, Illinois, managing the office, handling payroll, and making sure …
