bit.bio, the company coding human cells for novel cures and a pioneer in the field of synthetic biology, today announces its comprehensive program for Neuroscience 2024, the annual meeting of the Society for Neuroscience (SfN). This premier event, recognised as the world's largest forum for emerging neurological discoveries, will take place October 5-9, 2024, at Chicago's McCormick Place Convention Center.

bit.bio will showcase its ioCells Toolkit for neurodegenerative disease research, unveil important applications of its new CRISPR-Ready ioCells portfolio, and present data demonstrating unprecedented lot-to-lot consistency of ioCells - setting a new gold standard in cell model reproducibility. Attendees can visit booth #1545, where bit.bio experts will discuss how synthetic biology and cell advancements transform neuroscience research and drug discovery.

Breakthrough in Pain Research with ioSensory Neurons - Press Conference

Selected from over 10,500 submissions, bit.bio's Dr. Tony Oosterveen, Principal Scientist, will present at the SfN 2024 press conference on Monday, October 7, from 2-3 pm CDT in Room S501D. His talk, “Scalable iPSC programming strategy combined with optimised cocktails of neurotrophic factors yields functionally distinct nociceptor sensory neurons,” will introduce bit.bio's ioSensory Neurons. This novel human pain model could revolutionise next-generation pain medication development.

Addressing Reproducibility Crisis in Neuroscience Research - Expert Panel

On Monday, October 7, at 2:30 p.m. in Product Theater #2, bit.bio will host an expert panel discussion titled "Tackling the reproducibility crisis: the need for standardised human cell models for neuroscience research, drug discovery, and therapies.” This panel will explore how standardising human iPSC-derived cells can address the reproducibility crisis in neuroscience, potentially transforming research outcomes through enhanced consistency, improved reproducibility, and streamlined regulatory compliance across drug discovery and therapeutic development.

Host:

• Farah Patell-Socha: Vice President of Research Products at bit.bio

Panelists:

• Nicole Polinski: Director of Research Programs at The Michael J. Fox Foundation for Parkinson's Research
• Phil Mitchell: Director of Integrated Biology at Charles River Laboratories
• Paul Morrill: Chief Business Officer at bit.bio

Showcasing Stem Cell Models and Technologies - Poster Presentations

bit.bio and its partners will also present nine cutting-edge poster presentations. These diverse studies demonstrate the versatility and power of bit.bio's innovative ioCells across a wide spectrum of neuroscience research, including ALS/FTD, Alzheimer’s disease, Autism, Epilepsy, Huntington's disease, Multiple sclerosis, Neuroinflammation, and Schizophrenia. Each poster highlights bit.bio's opti-ox technology and its transformative impact on neurodegenerative disease modelling and drug discovery.

Poster Highlights

Sunday, October 6

• Modelling neurodegeneration using a human genetically matched system: A next-generation approach to study frontotemporal dementia and ALS. Session: ALS iPSC Models, 8 am-12 pm
• Scalable iPSC programming strategy, in combination with optimised cocktails of neurotrophic factors, yields functionally distinct nociceptor sensory neurons. Session: Pain Models With a Focus on Sex Differences, Human and In Vitro Approaches,8 am-12 pm
• Rapid and consistent generation of human iPSC-derived oligodendrocyte-like cells using opti-ox technology. Session: Theme A late-Breaking Posters, 8 am-12 pm
• Driving experimental reproducibility and lot-to-lot biological consistency in human iPSC-derived cells enabled by opti-ox technology. Session: Theme A late-Breaking Posters, 8 am-12 pm
• Establishment and validation of an in vitro co-culture model to study myelination using human iPSC-derived glutamatergic neurons and oligodendrocytes. Session: Multiple Sclerosis, Leukodystrophies, and Oligodendrocyte Myelination, featuring ioGlutamatergic Neurons, ioOligodendrocyte-like Cells,1 pm-5 pm, presented by partner Charles River Laboratories

Monday, October 7

• Harnessing CRISPR-ready ioGlutamatergic neurons and ioMicroglia for drug discovery in neurodegenerative diseases. Session: Molecular, Genetic, and Chemogenetic Tools for Neuronal Tagging, 8 am-12 pm
• An iPSC derived neuroinflammation in vitro model of neurons and glial cells. Session: Neuroinflammation and Neurodegeneration. Session: Studies in Humans and Human Tissues featuring ioGlutamatergic Neurons, ioMicroglia, ioOligodendrocyte-like Cells, 1 pm-5 pm, presented by partner Charles River Laboratories

Tuesday, October 8

• A scalable and well-defined human CNS co-culture platform suitable for studying excitatory/inhibitory neuron imbalances and discovering drugs to treat associated diseases. Session: Electrophysiological Recording of Neurons and Neural Networks, 8 am-12 pm
• Physiologically relevant media unmasks severe mitochondrial dysfunction in a deterministically programmed iPSC-derived model of Huntington’s disease. Session: Huntington’s Disease Molecular and Cellular Mechanisms in Mouse Models, 1 pm-5 pm

About bit.bio

bit.bio, a synthetic biology company, is democratising human cells to advance biomedical research (SDG9) and enable transformative treatments (SDG3). With Nobel Prize-winning science underpinning our understanding of cell identity as defined by unique combinations of transcription factors, our deterministic cell programming technology, opti-ox, enables conversion of induced pluripotent stem cells (iPSCs) into any desired human cell type in a single step. This is achieved within days and at industrial scale, while maintaining exceptional purity and consistency.

Since spinning out from the University of Cambridge and launching in 2016, we have raised approximately $200m from leading investors, including Arch Venture, Blueyard Capital, Charles River Laboratories, Foresite Capital, Milky Way, National Resilience, and Tencent.

For more information, please visit: www.bit.bio

For information on bit.bio’s trademarks, visit www.bit.bio/trademarks LinkedIn: https://www.linkedin.com/company/bitbioltd/

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