Human medicines European public assessment report (EPAR): Nexpovio, selinexor, Multiple Myeloma, Date of authorisation: 26/03/2021, Revision: 8, Status: Authorised
The most common side effects with Nexpovio used together with bortezomib and dexamethasone (which may affect more than 3 in 10 people) are thrombocytopenia (low blood platelet counts), nausea (feeling sick), tiredness, anaemia (low red blood cell counts), decreased appetite, diarrhoea and peripheral neuropathy (nerve damage in the arms and legs).
The most common serious side effects with Nexpovio used together with bortezomib and dexamethasone (which may affect up to 2 in 10 people) are pneumonia (lung infection), cataract, sepsis (blood poisoning), diarrhoea, vomiting and anaemia.
The most common side effects with Nexpovio used together with dexamethasone (which may affect more than 3 in 10 people) are nausea, vomiting, decreased appetite, weight loss, diarrhoea, tiredness, thrombocytopenia, anaemia, low levels of white blood cells and hyponatraemia (low blood sodium levels).
The most common serious side effects with Nexpovio used together with dexamethasone (which may affect up to 1 in 10 people) are pneumonia, sepsis, thrombocytopenia, anaemia and damage to the kidneys.
For the full list of side effects and restrictions of Nexpovio, see the package leaflet.
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