Neuroprotective Treatment Strategies in Multiple Sclerosis, New Webinar Hosted by Xtalks
Evotec is a drug-discovery solutions company offering the life sciences industry a variety of ways to access drug discovery innovation in a time efficient manner, as stand-alone or integrated projects and have the confidence that through creative deal making and high quality alliance and project management, their programmes are in safe hands.Click here for high-resolution version
/EINPresswire.com/ -- TORONTO, ON--(Marketwired - October 30, 2017) - The guest speakers for the live broadcast taking place on Friday, November 17, 2017 include Manuel Friese, MD, Professor of Neuroimmunology and Director of the Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, and Stephen Hess, PhD, Research Leader, Ion Channels, Evotec AG.
The TRPM4 ion channel is a member of the Transient Receptor Potential Melastatin family, and is permeable to monovalent cations but impermeable to calcium. Deletion of this gene in mice ameliorates the course of disease progression in an animal model of multiple sclerosis (MS). TRPM4 deletion does not influence the disease-relevant immune response in knockout mice in the animal model of MS.
TRPM4 is expressed in murine and human neurons, and is upregulated in axons in experimental autoimmune encephalomyelitis (EAE) and MS lesions. TRPM4 deletion substantially protects neuronal cells from excitotoxic challenges and energy deficiency; in part, this is thought to be due to excessive sodium influx through activated TRPM4 channels in diseased axons. TRPM4 blockade by glibenclamide, an unspecific blocker of this channel, exerts a similar neuroprotective property as its genetic deletion.
To find a specific inhibitor of TRPM4 channels to further define their role in MS, we screened a library of 250K small drug-like molecules using cells expressing human TRPM4 channels with a membrane potential dye readout. Hits were confirmed and profiled for concentration-dependent activity at TRPM4, selectivity against TRPM5 and host HEK cells, and tested in Automated Patch Clamp assays. Selected antagonist molecules from multiple chemical series are being optimized for testing in vivo.
For more information or to register for this complimentary session, visit: Neuroprotective Treatment Strategies in Multiple Sclerosis.
ABOUT XTALKS
Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global life science, food and medical device community. Every year thousands of industry practitioners (from life science, food and medical device companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.
To learn more about Xtalks visit http://xtalks.com
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Nima Rajan
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Email: nrajan@xtalks.com
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